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NVP-BGT226
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
NVP-BGT226图片
CAS NO:1245537-68-1
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议
200mg电议
10mM * 1mL in DMSO电议

产品名称
NVPBGT226, BGT226, BGT-226
产品介绍

生物活性

NVP-BGT226,新型磷酸肌醇3-激酶/mTOR双重抑制剂,作用于PI3Kα/β/γ,IC50为4 nM/63 nM/38 nM,在体外和体内对人的头颈癌细胞均显示出强大的生长抑制活性。

靶点信息

mTORPI3KαPI3KγPI3Kβ
N/A4 nM38 nM63 nM

化学数据

目录号A11162
作用机制Inhibitor (抑制剂)
M. Wt650.6
FormulaC28H25F3N6O2.C4H4O4
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.1245537-68-1
SynonymsNVPBGT226, BGT226, BGT-226
SMILESCN1C2=CN=C3C=CC(=CC3=C2N(C1=O)C4=CC(=C(C=C4)N5CCNCC5)C(F)(F)F)C6=CN=C(C=C6)OC.C(=C\C(=O)O)\C(=O)O

溶解度

In vitro (25°C)DMSO27 mg/mL (41.5 mM)
WaterInsoluble
EthanolInsoluble
In vivo30% PEG400+0.5% Tween80+5% propylene glycol28 mg/mL
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM15.37 mL76.85 mL153.7 mL
0.5 mM3.07 mL15.37 mL30.74 mL
1 mM1.54 mL7.69 mL15.37 mL
5 mM0.31 mL1.54 mL3.07 mL

*The above data is based on the productmolecular weight 650.6. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.