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1-Stearoyl-2-Arachidonoyl-sn-Glycerol
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
1-Stearoyl-2-Arachidonoyl-sn-Glycerol图片
CAS NO:65914-84-3
规格:98%
分子量:645
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议

产品介绍
Many protein kinase C (PKC) isoforms require activation via second messengers including Ca2+, diacylglycerol (DAG), and/or a phospholipid to phosphorylate target proteins and they initiate a variety of important signalling cascades.
CAS:65914-84-3
分子式:C41H72O5
分子量:645
纯度:98%
存储:Store at -20°C

Background:

Many protein kinase C (PKC) isoforms require activation via second messengers including Ca2+, diacylglycerol (DAG), and/or a phospholipid to phosphorylate target proteins and they initiate a variety of important signalling cascades. 1-Stearoyl-2-arachidonoyl-sn-glycerol (SAG) is a DAG that contains the ω-6 polyunsaturated fatty acid arachidonic acid in the sn-2 position and stearic acid in the sn-1 position of the glycerol backbone. It can potently activate PKCα, PKCε, and PKCδ at nM concentrations. Independent of PKC signalling, SAG competitively binds to the Ras activator RasGRP with a Ki value of 4.49 µM in Jurkat T-cells.