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R547
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
R547图片
CAS NO:741713-40-6
包装与价格:
包装价格(元)
5mg电议
25mg电议
50mg电议
10mM * 1mL in DMSO电议

产品名称
R-547
产品介绍

生物活性

R547是一种新型的细胞周期和转录周期依赖性激酶(CDKs)选择性抑制剂(CDK1,CDK2和CDK4分别为Ki = 1、3和1 nM),具有出色的体外细胞效价,可抑制各种细胞的生长。人肿瘤细胞系。

Targets

TargetValue
CDK4/CyclinD1ki: 1nM
CDK1/CyclinBki: 2nM
CDK2/CyclinEki: 3nM
PKAki: >5μM
PKBki: >5μM
PKCαki: >5μM
PKCβki: >5μM
Fynki: >5μM
EphB3ki: >5μM
SGKki: >5μM
KDRki: >5μM
FGFRki: >5μM
EGFRki: >5μM
PDGFRki: >5μM
IGFRki: >5μM
Srcki: >5μM
FAKki: >5μM
AuroraAki: >5μM
GSK-3βki: 8μM
p38ki: >50μM
MAPK2ki: >50μM

化学数据

目录号A11190
作用机制Inhibitor (抑制剂)
M. Wt441.45
FormulaC18H21F2N5O4S
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.741713-40-6
SynonymsR-547
SMILESCOC1=C(C(=C(C=C1)F)F)C(=O)C2=CN=C(N=C2N)NC3CCN(CC3)S(=O)(=O)C

溶解度

In vitro (25°C)DMSO56 mg/mL (126.85 mM)
WaterInsoluble
EthanolInsoluble
In vivo1% hydroxyethyl cellulose+0.2% Tween 8028 mg/mL
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM22.65 mL113.26 mL226.53 mL
0.5 mM4.53 mL22.65 mL45.31 mL
1 mM2.27 mL11.33 mL22.65 mL
5 mM0.45 mL2.27 mL4.53 mL

*The above data is based on the productmolecular weight 441.45. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.