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BMS 599626(AC480)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
BMS 599626(AC480)图片
CAS NO:873837-23-1
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议
100mg电议
10mM * 1mL in DMSO电议

产品名称
BMS-599626, BMS599626, AC-480
产品介绍

生物活性

BMS 599626 (AC480)是一种选择性的,高效效的HER1,HER2和HER4酪氨酸激酶抑制剂(IC50分别为22、32和190 nM),具有潜在的抗肿瘤活性。

化学数据

目录号A11209
作用机制Inhibitor (抑制剂)
M. Wt567.1
FormulaC27H27FN8O3.HCl
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.873837-23-1
SynonymsBMS-599626, BMS599626, AC-480
SMILESCC1=C2C(=NC=NN2C=C1NC(=O)OC[C@@H]3COCCN3)NC4=CC5=C(C=C4)N(N=C5)CC6=CC(=CC=C6)F.Cl

溶解度

In vitro (25°C)DMSO104 mg/mL (196.02 mM)
WaterInsoluble
Ethanol18 mg/mL (33.92 mM)
In vivo30% PEG400+0.5% Tween80+5% propylene glycol28 mg/mL
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM17.63 mL88.17 mL176.34 mL
0.5 mM3.53 mL17.63 mL35.27 mL
1 mM1.76 mL8.82 mL17.63 mL
5 mM0.35 mL1.76 mL3.53 mL

*The above data is based on the productmolecular weight 567.1. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.