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A-54556A
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
A-54556A图片
CAS NO:95398-45-1
规格:98%
分子量:718.9
包装与价格:
包装价格(元)
1mg电议
5mg电议

产品介绍
natural acyldepsipeptide (ADEP) antibiotic
CAS:95398-45-1
分子式:C38H50N6O8
分子量:718.9
纯度:98%
存储:Store at -20°C

Background:

IC50: 0.2 μg/ml for Bacillus subtilis 168


A-54556A is a natural acyldepsipeptide (ADEP) antibiotic.


Acyldepsipeptides (ADEP), a new class of antibiotics, has antibacterial activity against Gram-positive bacteria. The acyldepsipeptides are active against isolates that are resistant to antibiotics, implying a new target identify as ClpP.


In vitro: Previous study found that the treatment of B. subtilis with 1.6 mg/ml of A-54556A reduced the number of viable cells by 2 log units. In addition, the biosynthesis of DNA, RNA, protein, cell wall and fatty acid proceeded unhindered for 1 h at 2 mg/ml A-54556A, whereas classical antibiotics were clearly distinguished by preferential inhibition of their target pathway. Microscopic examination showed that after addition of A-54556A at concentrations as low as 0.4 mg/ml, B. subtilis started to form filaments [1].


In vivo: Two A-54556A analogs, ADEP 2 and ADEP 4, were proven to be active in the treatment of bacterial infections in rodents. When mice were challenged with a lethal systemic infection of E. faecalis, 1 mg/kg ADEP 2 or 0.5 mg/kg ADEP 4 were sufficient for 100% survival. In lethal sepsis caused by S. aureus, 12.5 mg/kg ADEP 4 rescued 80% of the mice and reduced the bacterial loads in liver, spleen and lung by 2–3 log units compared to an untreated control [1].


Clinical trial: Up to now, A-54556A is still in the preclinical development stage.


Reference:
[1] H.  Brtz-Oesterhelt, D. Beyer, H. P. Kroll, et al. Dysregulation of bacterial proteolytic machinery by a new class of antibiotics. Nature Medicine 11(10), 1082-1087 (2005).