您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > LY 2874455
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
LY 2874455
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
LY 2874455图片
CAS NO:1254473-64-7
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
10mM * 1mL in DMSO电议

产品名称
LY-2874455, LY2874455
产品介绍

生物活性

LY2874455是一种新型有效的FGFR / VEGFR抑制剂。

靶点信息

FGFR2FGFR1FGFR4FGFR3VEGFR2
2.6 nM2.8 nM6 nM6.4 nM7 nM

化学数据

目录号A11244
作用机制Inhibitor (抑制剂)
M. Wt444.31
FormulaC21H19Cl2N5O2
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.1254473-64-7
SynonymsLY-2874455, LY2874455
SMILESC[C@H](C1=C(C=NC=C1Cl)Cl)OC2=CC3=C(C=C2)NN=C3/C=C/C4=CN(N=C4)CCO

溶解度

In vitro (25°C)DMSO86 mg/mL (193.55 mM)
WaterInsoluble
EthanolWarmed: 56 mg/mL (126.03 mM)
In vivo2% DMSO+30% PEG 300+5% Tween 80+ddH2O4 mg/mL
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM22.51 mL112.53 mL225.07 mL
0.5 mM4.5 mL22.51 mL45.01 mL
1 mM2.25 mL11.25 mL22.51 mL
5 mM0.45 mL2.25 mL4.5 mL

*The above data is based on the productmolecular weight 444.31. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.