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Cobicistat(GS-9350)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Cobicistat(GS-9350)图片
CAS NO:1004316-88-4
包装与价格:
包装价格(元)
2mg电议
5mg电议
10mg电议
25mg电议
10mM * 1mL in DMSO电议

产品名称
GS9350
产品介绍

生物活性

Cobicistat (GS-9350)是有效,选择性的细胞色素酶P450 3A (CYP3A)抑制剂,包括重要的cyp3a4亚型。它还抑制肠道转运蛋白,增加几种hiv药物的整体吸收,包括atazanavir、darunavir和tenofovir alafenamide延胡索酸盐。

靶点信息

CYP3A
30 nM-285 nM

化学数据

目录号A11277
作用机制Inhibitor (抑制剂)
M. Wt766.0
FormulaC40H53N7O5S2
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.1004316-88-4
SynonymsGS9350
SMILESCC(C)C1=NC(=CS1)CN(C)C(=O)N[C@@H](CCN2CCOCC2)C(=O)N[C@H](CC[C@H](CC3=CC=CC=C3)NC(=O)OCC4=CN=CS4)CC5=CC=CC=C5

溶解度

In vitro (25°C)DMSO85 mg/mL (109.53 mM)
WaterInsoluble
Ethanol85 mg/mL (109.53 mM)
In vivo5% DMSO+40% PEG 300+ddH2O9 mg/mL
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM13.05 mL65.27 mL130.55 mL
0.5 mM2.61 mL13.05 mL26.11 mL
1 mM1.31 mL6.53 mL13.05 mL
5 mM0.26 mL1.31 mL2.61 mL

*The above data is based on the productmolecular weight 766.0 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.