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AKT inhibitor VIII(AKTi-1/2)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
AKT inhibitor VIII(AKTi-1/2)图片
CAS NO:612847-09-3
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议

产品介绍

生物活性

AKT inhibitor VIII (AKTI-1/2)是一种细胞可渗透且可逆的喹喔啉化合物,在体外激酶测定中,该化合物有效和选择性地抑制Akt1/Akt2活性(对于Akt1,Akt2和Akt3,IC50分别为58 nM,210 nM和2.12μM)。

靶点信息

Akt1Akt2Akt3
58 nM210 nM2119 nM

化学数据

目录号A11286
作用机制Inhibitor (抑制剂)
M. Wt551.6
FormulaC34H29N7O
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.612847-09-3
SMILESC1CN(CCC1N2C3=CC=CC=C3NC2=O)CC4=CC=C(C=C4)C5=NC6=CC7=C(C=C6N=C5C8=CC=CC=C8)N=CN7

溶解度

In vitroDMSO19 mg/mL (34.44 mM)
WaterInsoluble
EthanolInsoluble
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM18.13 mL90.65 mL181.29 mL
0.5 mM3.63 mL18.13 mL36.26 mL
1 mM1.81 mL9.06 mL18.13 mL
5 mM0.36 mL1.81 mL3.63 mL

*The above data is based on the productmolecular weight 551.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.