生物活性
Apremilast (CC 10004)是一种新型的PDE4抑制剂，可抑制人类风湿性滑膜细胞自发产生肿瘤坏死因子-α，并改善实验性关节炎。
化学数据
| 目录号 | A11289 |
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 460.5 |
| Formula | C22H24N2O7S |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. | 608141-41-9 |
| Synonyms | CC10004, CC-10004 |
| SMILES | CCOC1=C(C=CC(=C1)[C@@H](CS(=O)(=O)C)N2C(=O)C3=C(C2=O)C(=CC=C3)NC(=O)C)OC |
溶解度
| In vitro (25°C) | DMSO | 85 mg/mL (184.58 mM) |
| Water | Insoluble |
| Ethanol | Insoluble |
| In vivo | 0.5% CMC+0.25% Tween 80 | 28 mg/mL |
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
| 0.1 mM | 21.72 mL | 108.58 mL | 217.16 mL |
| 0.5 mM | 4.34 mL | 21.72 mL | 43.43 mL |
| 1 mM | 2.17 mL | 10.86 mL | 21.72 mL |
| 5 mM | 0.43 mL | 2.17 mL | 4.34 mL |
*The above data is based on the productmolecular weight 460.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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