生物活性
SYN115是口服,有效和选择性的腺苷2a(A2a)受体抑制剂,作用于人类和恒河猴的 adenosine A2A 受体,Ki 值分别为 11.5 nM 和 6 nM。
化学数据
目录号 | A11560 |
作用机制 | Antagonist (拮抗剂) |
M. Wt | 406.5 |
Formula | C19H26N4O4S |
Purity | >99% |
Storage | Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for36 months. In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
CAS No. | 870070-55-6 |
Synonyms | SYN115, Tozadenant |
SMILES | CC1(CCN(CC1)C(=O)NC2=NC3=C(C=CC(=C3S2)N4CCOCC4)OC)O |
储备液配制
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
0.1 mM | 24.6 mL | 123 mL | 246 mL |
0.5 mM | 4.92 mL | 24.6 mL | 49.2 mL |
1 mM | 2.46 mL | 12.3 mL | 24.6 mL |
5 mM | 0.49 mL | 2.46 mL | 4.92 mL |
*The above data is based on the productmolecular weight 406.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.