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TAK-715
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
TAK-715图片
CAS NO:303162-79-0
包装与价格:
包装价格(元)
10mg电议
25mg电议
50mg电议
100mg电议
10mM * 1mL in DMSO电议

产品名称
TAK715, TAK 715
产品介绍

生物活性

TAK 715是p38 MAPK抑制剂(p38MAPKα的IC50 = 7.1 nM),Wnt /β-catenin信号传导抑制剂,并抑制22种激酶(包括CK1δ/ε)超过80%。

Targets

TargetValue
p38αIC50: 7.1nM
p38βIC50: 0.20μM
p38γIC50: >10μM
p38δIC50: >10μM
JNK1IC50: >10μM
ERK1IC50: >10μM
IKKβIC50: >10μM
MEKK1IC50: >10μM
TAK1IC50: >10μM

化学数据

目录号A11582
作用机制Inhibitor (抑制剂)
M. Wt399.51
FormulaC24H21N3OS
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.303162-79-0
SynonymsTAK715, TAK 715
SMILESCCC1=NC(=C(S1)C2=CC(=NC=C2)NC(=O)C3=CC=CC=C3)C4=CC(=CC=C4)C

溶解度

In vitro (25°C)DMSO72 mg/mL (180.22 mM)
WaterInsoluble
Ethanol14 mg/mL (35.04 mM)
In vivo30% propylene glycol, 5% Tween 80, 65% D5W28 mg/mL
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM25.03 mL125.15 mL250.31 mL
0.5 mM5.01 mL25.03 mL50.06 mL
1 mM2.5 mL12.52 mL25.03 mL
5 mM0.5 mL2.5 mL5.01 mL

*The above data is based on the productmolecular weight 399.51. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.