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Tideglusib
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Tideglusib图片
CAS NO:865854-05-3
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议

产品介绍

生物活性

Tideglusib是一种不可逆的,非ATP竞争性的GSK-3β抑制剂,无细胞试验中IC50为60 nM。用于治疗阿尔茨海默氏病和进行性核上性麻痹。

化学数据

目录号A11592
作用机制Inhibitor (抑制剂)
M. Wt334.39
FormulaC19H14N2O2S
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.865854-05-3
SMILESC1=CC=C(C=C1)CN2C(=O)N(SC2=O)C3=CC=CC4=CC=CC=C43

溶解度

In vitro (25°C)DMSOWarmed: 7 mg/mL (20.93 mM)
WaterInsoluble
EthanolInsoluble
In vivo4% DMSO+corn oil2.3 mg/mL
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM29.91 mL149.53 mL299.05 mL
0.5 mM5.98 mL29.91 mL59.81 mL
1 mM2.99 mL14.95 mL29.91 mL
5 mM0.6 mL2.99 mL5.98 mL

*The above data is based on the productmolecular weight 334.39. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.