JAK2/FLT3/TrkA inhibitor
CAS：111358-88-4
分子式：C25H21N3O4
分子量：439.46
纯度：98%
存储：Store at -20°C

Background:

Potent JAK2, FLT3 and TrkA inhibitor (IC₅₀values are 0.9, 3 and < 25 nM respectively) that prevents STAT5 phosphorylation (IC₅₀= 20 - 30 nM). Exhibits antiproliferative activityin vitro(IC₅₀= 30 - 100 nM in HEL92.1.7 cells) and is effective against myeloproliferative disordersin vivo.