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Tubastatin A(trifluoroacetate salt)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Tubastatin A(trifluoroacetate salt)图片
CAS NO:1239262-52-2
规格:98%
分子量:449.4
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
Tubastatin A is a potent HDAC6 inhibitor with an IC50 value of 15 nM.
CAS:1239262-52-2
分子式:C20H21N3O2.CF3COOH
分子量:449.4
纯度:98%
存储:Store at -20°C

Background:

Tubastatin A is a potent HDAC6 inhibitor with an IC50 value of 15 nM. Comparatively, it demonstrates over 1,000-fold selectivity against all other HDAC isoforms (IC50s >16 μM), excluding HDAC8 (IC50 = 0.9 μM). Tubastatin A induces α-tubulin hyperacetylation at 2.5 μM in primary cortical neuron cultures. In a model of oxidative stress induced by glutathione depletion, tubastatin A displays dose-dependent neuronal protection of primary cortical neuron cultures at 5-10 μM.