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Z-Ile-Leu-aldehyde
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Z-Ile-Leu-aldehyde图片
CAS NO:161710-10-7
规格:98%
分子量:362.46
包装与价格:
包装价格(元)
5mg电议
10mg电议

产品介绍
potent gamma-Secretase inhibitor
CAS:161710-10-7
分子式:C20H30N2O4
分子量:362.46
纯度:98%
存储:Store at -20°C

Background:

Z-Ile-Leu-aldehyde (gamma-Secretase inhibitor XII /GSI XII, Z-IL-CHO) is a potent gamma-Secretase inhibitor and Notch signaling inhibitor.


Notch signaling impinges on many cellular processes, including cell proliferation, differentiation, apoptosis, and maintenance of stem cells. It is also involved in many developmental systems, including neurogenesis, angiogenesis, hematopoiesis, and myogenesis. Deregulation of Notch signaling leads to developmental syndromes and cancer [3]. In order to transmit a signal, Notch receptors undergo a series of proteolytic cleavages after binding their cognate ligands of the Delta-like and Jagged family. γ-Secretase is a large protease complex that cleaves the membrane-bound form of Notch and releases the intracellular domain of the Notch receptor. This step in Notch signaling is pivotal in the activation of this signaling cascade [1] [2].


In vitro: GSI XII (10