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Lapatinib(free base)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Lapatinib(free base)图片
CAS NO:231277-92-2
包装与价格:
包装价格(元)
10mg电议
25mg电议
50mg电议
100mg电议
10mM * 1mL in DMSO电议

产品介绍

生物活性

Lapatinib (free base)是一种双重酪氨酸激酶抑制剂,是一种有效的EGFR和ErbB2抑制剂,在无细胞试验中IC50分别为10.2和9.8 nM。可阻断HER2生长受体途径。

Targets

TargetValue
ErbB2IC50: 9.2nM
EGFRIC50: 10.8nM
ErbB4IC50: 367nM
c-SrcIC50: 3.5μM
C-Raf-1IC50: >10μM
MEKIC50: >10μM
ERKIC50: >10μM
c-FmsIC50: >10μM
CDK1IC50: >10μM
CDK2IC50: >10μM
p38IC50: >10μM
Tie-2IC50: >10μM
VEGFR2IC50: >10μM

化学数据

目录号A11752
M. Wt581.1
FormulaC29H26ClFN4O4S
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.231277-92-2
SMILESCS(=O)(=O)CCNCC1=CC=C(O1)C2=CC3=C(C=C2)N=CN=C3NC4=CC(=C(C=C4)OCC5=CC(=CC=C5)F)Cl

溶解度

In vitro (25°C)DMSO99 mg/mL (170.37 mM)
WaterInsoluble
EthanolInsoluble
In vivo2% DMSO+30% PEG 300+5% Tween 80+ddH2O9 mg/mL
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM17.21 mL86.04 mL172.09 mL
0.5 mM3.44 mL17.21 mL34.42 mL
1 mM1.72 mL8.6 mL17.21 mL
5 mM0.34 mL1.72 mL3.44 mL

*The above data is based on the productmolecular weight 581.1 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.