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PF 4708671
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
PF 4708671图片
CAS NO:1255517-76-0
包装与价格:
包装价格(元)
10mg电议
25mg电议
50mg电议
100mg电议
10mM * 1mL in DMSO电议

产品名称
PF4708671, PF-4708671
产品介绍

生物活性

PF 4708671是p70核糖体S6激酶(S6K1)的高度特异性抑制剂,可抑制S6K1介导的IGF-1磷酸化S6蛋白的磷酸化,而对高度相关的RSK和MSK激酶没有影响。

靶点信息

p70 S6K1 (Cell-free assay)
160 nM

化学数据

目录号A11755
作用机制Inhibitor (抑制剂)
M. Wt390.4
FormulaC19H21F3N6
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.1255517-76-0
SynonymsPF4708671, PF-4708671
SMILESCCC1=CN=CN=C1N2CCN(CC2)CC3=NC4=C(N3)C=C(C=C4)C(F)(F)F

溶解度

In vitro (25°C)DMSO30 mg/mL (76.84 mM)
WaterInsoluble
Ethanol8 mg/mL (20.49 mM)
In vivo30% PEG400+0.5% Tween80+5% propylene glycol28 mg/mL
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM25.61 mL128.07 mL256.15 mL
0.5 mM5.12 mL25.61 mL51.23 mL
1 mM2.56 mL12.81 mL25.61 mL
5 mM0.51 mL2.56 mL5.12 mL

*The above data is based on the productmolecular weight 390.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.