生物活性
Prucalopride是一种选择性的，高亲和力的5-HT4受体激动剂，作用于5-HT4A和5-HT4B受体，Ki分别为2.5 nM和8 nM，比作用于5-HT受体亚型选择性高290倍以上。
Targets
| Target | Value |
| 5-HT4A | ki: 2.5nM |
| 5-HT4B | ki: 8nM |
| 5-HT3 | ki: 3.822μM |
| 5-HT1A | ki: >10μM |
| 5-HT1B | ki: >10μM |
| 5-HT1D | ki: >10μM |
| 5-HT1E | ki: >10μM |
| 5-HT1F | ki: >10μM |
| 5-HT2A | ki: >10μM |
| 5-HT2B | ki: >10μM |
| 5-HT2C | ki: >10μM |
| 5-HT5A | ki: >10μM |
| 5-HT6 | ki: >10μM |
| 5-HT7 | ki: >10μM |
化学数据
| 目录号 | A11771 |
| 作用机制 | Agonist (激动剂) |
| M. Wt | 367.9 |
| Formula | C18H26ClN3O3 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. | 179474-81-8 |
| Synonyms | Resolor |
| SMILES | COCCCN1CCC(CC1)NC(=O)C2=CC(=C(C3=C2OCC3)N)Cl |
溶解度
| In vitro | DMSO | 52 mg/mL (141.35 mM) |
| Water | Insoluble |
| Ethanol | 33 mg/mL (89.7 mM) |
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
| 0.1 mM | 27.18 mL | 135.91 mL | 271.81 mL |
| 0.5 mM | 5.44 mL | 27.18 mL | 54.36 mL |
| 1 mM | 2.72 mL | 13.59 mL | 27.18 mL |
| 5 mM | 0.54 mL | 2.72 mL | 5.44 mL |
*The above data is based on the productmolecular weight 367.9 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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