生物活性
Azilsartan (TAK-536)是一种用于治疗高血压的血管紧张素II受体拮抗剂。
靶点信息
化学数据
| 目录号 | A11775 |
| 作用机制 | Blocker (阻断剂) |
| M. Wt | 456.5 |
| Formula | C25H20N4O5 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. | 147403-03-0 |
| Synonyms | TAK536 |
| SMILES | CCOC1=NC2=CC=CC(=C2N1CC3=CC=C(C=C3)C4=CC=CC=C4C5=NC(=O)ON5)C(=O)O |
溶解度
| In vitro (25°C) | DMSO | 78 mg/mL (170.88 mM) |
| Water | Insoluble |
| Ethanol | Insoluble |
| In vivo | 30% PEG400+0.5% Tween80+5% propylene glycol | 28 mg/mL |
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
| 0.1 mM | 21.91 mL | 109.53 mL | 219.06 mL |
| 0.5 mM | 4.38 mL | 21.91 mL | 43.81 mL |
| 1 mM | 2.19 mL | 10.95 mL | 21.91 mL |
| 5 mM | 0.44 mL | 2.19 mL | 4.38 mL |
*The above data is based on the productmolecular weight 456.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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