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dBET6
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
dBET6图片
CAS NO:1950634-92-0
规格:98%
分子量:841.37
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
dBET6是一种高效的,选择性的,细胞透过的基于PROTAC技术的BET降解剂,IC50值为14nM,具有抗肿瘤活性。
CAS:1950634-92-0
分子式:C42H45ClN8O7S
分子量:841.37
纯度:98%
存储:Store at -20°C

Background:

dBET6 is a highly potent, selective and cell-permeable degrader of BET based on PROTAC, with an IC50 of 14 nM, and has antitumor activity.


dBET6 is a highly potent, selective and cell-permeable degrader of BET with an IC50 of 14 nM. dBET6 (100 nM) exhibits antitumor activity against T cell acute lymphoblastic leukemia (T-ALL) lines via degradation of BRD4[1].


dBET6 (7.5 mg/kg, p.o., BID) reduces the leukemic burden in a disseminated mouse model of T-ALL[1].


[1]. Winter GE, et al. BET Bromodomain Proteins Function as Master Transcription Elongation Factors Independent of CDK9 Recruitment. Mol Cell. 2017 Jul 6;67(1):5-18.e19.