GT949是一种选择性的兴奋性氨基酸转运蛋白-2(EAAT2)阳性变构调节剂，EC50为0.26nM。
CAS：460330-27-2
分子式：C30H37N7O2
分子量：527.66
纯度：98%
存储：Store at -20°C

Background:

GT 949 is a selective excitatory amino acid transporter-2 (EAAT2) positive allosteric modulator with an EC50 of 0.26 nM[1].

GT 949 (GT949) enhances glutamate transport with an EC50 of 0.26 ± 0.03 nM. GT 949 also demonstrates selectivity to EAAT2 and has no effect on glutamate activity mediated by EAAT1 or EAAT3[1].GT 949 is also tested for its effect on glutamate uptake kinetics in EAAT2-transfected cells. GT 949 enhances glutamate transport in a noncompetitive fashion, with increase in Vmax of about 47%[1].

[1]. Kortagere S, et al. Identification of Novel Allosteric Modulators of Glutamate Transporter EAAT2. ACS Chem Neurosci. 2018 Mar 21;9(3):522-534.