您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > GT 949
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
GT 949
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
GT 949图片
CAS NO:460330-27-2
规格:98%
分子量:527.66
包装与价格:
包装价格(元)
5mg电议
10mg电议

产品介绍
GT949是一种选择性的兴奋性氨基酸转运蛋白-2(EAAT2)阳性变构调节剂,EC50为0.26nM。
CAS:460330-27-2
分子式:C30H37N7O2
分子量:527.66
纯度:98%
存储:Store at -20°C

Background:

GT 949 is a selective excitatory amino acid transporter-2 (EAAT2) positive allosteric modulator with an EC50 of 0.26 nM[1].


GT 949 (GT949) enhances glutamate transport with an EC50 of 0.26 ± 0.03 nM. GT 949 also demonstrates selectivity to EAAT2 and has no effect on glutamate activity mediated by EAAT1 or EAAT3[1].GT 949 is also tested for its effect on glutamate uptake kinetics in EAAT2-transfected cells. GT 949 enhances glutamate transport in a noncompetitive fashion, with increase in Vmax of about 47%[1].



[1]. Kortagere S, et al. Identification of Novel Allosteric Modulators of Glutamate Transporter EAAT2. ACS Chem Neurosci. 2018 Mar 21;9(3):522-534.