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Apalutamide(ARN-509)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Apalutamide(ARN-509)图片
CAS NO:956104-40-8
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
10mM * 1mL in DMSO电议

产品名称
ARN509
产品介绍

生物活性

Apalutamide (ARN-509)是一种具有潜在抗肿瘤活性的雄激素受体拮抗剂,IC50 为 16 nM。ARN-509与靶组织中的AR结合,从而阻止了雄激素诱导的受体激活,并促进了无法转运至细胞核的无活性复合物的形成。这防止了AR应答基因的结合和转录。

靶点信息

Androgen Receptor (Cell-free assay)GABAA receptor (Cell-free assay)
16 nM3 μM

化学数据

目录号A11923
作用机制Inhibitor (抑制剂)
M. Wt477.4
FormulaC21H15F4N5O2S
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.956104-40-8
SynonymsARN509
SMILESCNC(=O)C1=C(C=C(C=C1)N2C(=S)N(C(=O)C23CCC3)C4=CN=C(C(=C4)C(F)(F)F)C#N)F

溶解度

In vitro (25°C)DMSO18 mg/mL (37.7 mM)
WaterInsoluble
Ethanol5 mg/mL (10.47 mM)
In vivo2% DMSO+40% PEG 300+2% Tween 80+ddH2O2 mg/mL
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM20.95 mL104.73 mL209.47 mL
0.5 mM4.19 mL20.95 mL41.89 mL
1 mM2.09 mL10.47 mL20.95 mL
5 mM0.42 mL2.09 mL4.19 mL

*The above data is based on the productmolecular weight 477.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.