生物活性
IOX2是一种有效的HIF-1α脯氨酰羟化酶2(PHD2)抑制剂,在无细胞分析中的IC50为21 nM,选择性是JMJD2A,JMJD2C,JMJD2E,JMJD3或2OG加氧酶FIH的100倍以上。
靶点信息
PHD2 (Cell-free assay) | | | | |
21 nM | | | | |
化学数据
目录号 | A11924 |
作用机制 | Inhibitor (抑制剂) |
M. Wt | 352.3 |
Formula | C19H16N2O5 |
Purity | >99% |
Storage | Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for36 months. In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
CAS No. | 931398-72-0 |
Synonyms | IOX-2, IOX2 |
SMILES | C1=CC=C(C=C1)CN2C3=CC=CC=C3C(=C(C2=O)C(=O)NCC(=O)O)O |
溶解度
In vitro (25°C) | DMSO | 7 mg/mL (19.86 mM) |
Water | Insoluble |
Ethanol | Insoluble |
In vivo | 5% DMSO+30% PEG 300+ddH2O | 1 mg/mL |
*<1 mg/ml means slightly soluble or insoluble. *Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
0.1 mM | 28.38 mL | 141.92 mL | 283.85 mL |
0.5 mM | 5.68 mL | 28.38 mL | 56.77 mL |
1 mM | 2.84 mL | 14.19 mL | 28.38 mL |
5 mM | 0.57 mL | 2.84 mL | 5.68 mL |
*The above data is based on the productmolecular weight 352.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.