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R788(Fostamatinib)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
R788(Fostamatinib)图片
CAS NO:901119-35-5
包装与价格:
包装价格(元)
2mg电议
5mg电议
10mg电议
25mg电议
10mM * 1mL in DMSO电议

产品名称
R-788
产品介绍

生物活性

R788 (Fostamatinib)是重要的脾酪氨酸激酶(Syk)抑制剂,显示出对激酶介导的IgG Fcγ受体信号转导的功效。

靶点信息

SykAdenosine A3 receptorAdenosine transporterMonoamine transporter
41 nM81 nM1.84 μM2.74 μM

化学数据

目录号A11926
作用机制Inhibitor (抑制剂)
M. Wt580.5
FormulaC23H26FN6O9P
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.901119-35-5
SynonymsR-788
SMILESCC1(C(=O)N(C2=C(O1)C=CC(=N2)NC3=NC(=NC=C3F)NC4=CC(=C(C(=C4)OC)OC)OC)COP(=O)(O)O)C

溶解度

In vitro (25°C)DMSO107 mg/mL (184.34 mM)
WaterInsoluble
EthanolInsoluble
In vivo4% DMSO+30% PEG 300+ddH2O4 mg/mL
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM17.23 mL86.13 mL172.27 mL
0.5 mM3.45 mL17.23 mL34.45 mL
1 mM1.72 mL8.61 mL17.23 mL
5 mM0.34 mL1.72 mL3.45 mL

*The above data is based on the productmolecular weight 580.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.