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N-Benzylacetamidine(hydrobromide)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
N-Benzylacetamidine(hydrobromide)图片
CAS NO:186545-76-6
规格:98%
分子量:229.1
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议
100mg电议

产品介绍
iNOS inhibitor
CAS:186545-76-6
分子式:C9H12N2 · HBr
分子量:229.1
纯度:98%
存储:Store at -20°C

Background:

IC50: 0.20 μM: inhibits inducible nitric oxide synthases (iNOS).


IC50: 350 μM: blocks endothelial nitric oxide synthases (eNOS).


N-Benzylacetamidine is a potent and selective inhibitor of iNOS compared to eNOS. NOS is essential to the formation of nitric oxide (NO) via the NADPH- and O2-dependent oxidation of L-arginine, which plays a role in regulating many pathological and physiological processes, including smooth muscle relaxation and neurotransmission. INOS contributes to immune response and inflammation while eNOS plays a vital role in regulating vascular tone.


In vitro: N-Benzylacetamidine showed good iNOS and almost negligible eNOS inhibition in THP-1 cells, a human myelomonocytic leukemia cell line [1].


In vivo: Up to now, in vivo study of N-Benzylacetamidine is still in the development stage.


Reference:
[1].  Maccallini, C., Patruno, A., Besker, N., Ali, J., Ammazzalorso, A., & De Filippis, B. et al. Synthesis, Biological Evaluation, and Docking Studies of N-Substituted Acetamidines as Selective Inhibitors of Inducible Nitric Oxide Synthase. Journal of Medicinal Chemistry. 2009; 52(5): 1481-1485.