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LCL-161
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
LCL-161图片
CAS NO:1005342-46-0
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
10mM * 1mL in DMSO电议

产品名称
LCL161, LCL 161
产品介绍

生物活性

LCL161是口服生物可利用的第二个线粒体衍生的半胱天冬酶(SMAC)类似物激活剂,也是IAP(细胞凋亡抑制蛋白)家族蛋白的抑制剂,具有潜在的抗肿瘤活性,抑制 HEK293 细胞中 XIAP 和 MDA-MB-231细胞中 cIAP1 的 IC50分别为 35 和 0.4 nM。

靶点信息

cIAPXIAP

化学数据

目录号A11928
作用机制Antagonist (拮抗剂)
M. Wt500.2
FormulaC26H33FN4O3S
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.1005342-46-0
SynonymsLCL161, LCL 161
SMILESC[C@@H](C(=O)N[C@@H](C1CCCCC1)C(=O)N2CCC[C@H]2C3=NC(=CS3)C(=O)C4=CC=C(C=C4)F)NC

溶解度

In vitroDMSO86 mg/mL (171.78 mM)
WaterInsoluble
EthanolWarmed: 17 mg/mL (33.95 mM)
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM19.99 mL99.96 mL199.92 mL
0.5 mM4 mL19.99 mL39.98 mL
1 mM2 mL10 mL19.99 mL
5 mM0.4 mL2 mL4 mL

*The above data is based on the productmolecular weight 500.2 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.