生物活性
PF-3758309是抑制致癌信号和肿瘤生长的小分子p21活化激酶抑制剂。
Targets
| Target | Value |
| PAK4 | IC50: 1.3nM |
| PAK1 | ki: 13.7nM |
| PAK6 | ki: 17.1nM |
| PAK5 | ki: 18.1nM |
| PAK4 | ki: 18.7nM |
| PAK3 | IC50: 99nM |
| PAK2 | IC50: 190nM |
化学数据
| 目录号 | A11930 |
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 490.2 |
| Formula | C25H30N8OS |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. | 898044-15-0 |
| Synonyms | PF-03758309 |
| SMILES | CC1=NC2=C(C(=N1)NC3=NNC4=C3CN(C4(C)C)C(=O)N[C@H](CN(C)C)C5=CC=CC=C5)SC=C2 |
溶解度
| In vitro | DMSO | 87 mg/mL (177.32 mM) |
| Water | Insoluble |
| Ethanol | 87 mg/mL (177.32 mM) |
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
| 0.1 mM | 20.4 mL | 102 mL | 204 mL |
| 0.5 mM | 4.08 mL | 20.4 mL | 40.8 mL |
| 1 mM | 2.04 mL | 10.2 mL | 20.4 mL |
| 5 mM | 0.41 mL | 2.04 mL | 4.08 mL |
*The above data is based on the productmolecular weight 490.2 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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