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ACY-1215(Rocilinostat)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
ACY-1215(Rocilinostat)图片
CAS NO:1316214-52-4
包装与价格:
包装价格(元)
10mg电议
50mg电议
100mg电议
10mM * 1mL in DMSO电议

产品名称
ACY1215
产品介绍

生物活性

ACY-1215 (Rocilinostat)是一种选择性HDAC6抑制剂,从而通过Hsp90的超乙酰化作用破坏Hsp90蛋白伴侣系统,并防止随后的总蛋白降解。

Targets

TargetValue
HDAC6IC50: 4.7nM
HDAC2IC50: 48nM
HDAC3IC50: 51nM
HDAC1IC50: 58nM
HDAC8IC50: 100nM
HDAC7IC50: 1.4μM
HDAC5IC50: 5μM
HDAC4IC50: 7μM
HDAC9IC50: >10μM
HDAC11IC50: >10μM
Sirtuin1IC50: >10μM
Sirtuin2IC50: >10μM

化学数据

目录号A11940
作用机制Inhibitor (抑制剂)
M. Wt433.5
FormulaC24H27N5O3
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.1316214-52-4
SynonymsACY1215
SMILESC1=CC=C(C=C1)N(C2=CC=CC=C2)C3=NC=C(C=N3)C(=O)NCCCCCCC(=O)NO

溶解度

In vitro (25°C)DMSO73 mg/mL (168.39 mM)
WaterInsoluble
EthanolInsoluble
In vivo2% DMSO+30% PEG 300+ddH2O4 mg/mL
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM23.07 mL115.34 mL230.68 mL
0.5 mM4.61 mL23.07 mL46.14 mL
1 mM2.31 mL11.53 mL23.07 mL
5 mM0.46 mL2.31 mL4.61 mL

*The above data is based on the productmolecular weight 433.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.