生物活性
ACY-1215 (Rocilinostat)是一种选择性HDAC6抑制剂,从而通过Hsp90的超乙酰化作用破坏Hsp90蛋白伴侣系统,并防止随后的总蛋白降解。
Targets
Target | Value |
HDAC6 | IC50: 4.7nM |
HDAC2 | IC50: 48nM |
HDAC3 | IC50: 51nM |
HDAC1 | IC50: 58nM |
HDAC8 | IC50: 100nM |
HDAC7 | IC50: 1.4μM |
HDAC5 | IC50: 5μM |
HDAC4 | IC50: 7μM |
HDAC9 | IC50: >10μM |
HDAC11 | IC50: >10μM |
Sirtuin1 | IC50: >10μM |
Sirtuin2 | IC50: >10μM |
化学数据
目录号 | A11940 |
作用机制 | Inhibitor (抑制剂) |
M. Wt | 433.5 |
Formula | C24H27N5O3 |
Purity | >99% |
Storage | Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for36 months. In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
CAS No. | 1316214-52-4 |
Synonyms | ACY1215 |
SMILES | C1=CC=C(C=C1)N(C2=CC=CC=C2)C3=NC=C(C=N3)C(=O)NCCCCCCC(=O)NO |
溶解度
In vitro (25°C) | DMSO | 73 mg/mL (168.39 mM) |
Water | Insoluble |
Ethanol | Insoluble |
In vivo | 2% DMSO+30% PEG 300+ddH2O | 4 mg/mL |
*<1 mg/ml means slightly soluble or insoluble. *Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
0.1 mM | 23.07 mL | 115.34 mL | 230.68 mL |
0.5 mM | 4.61 mL | 23.07 mL | 46.14 mL |
1 mM | 2.31 mL | 11.53 mL | 23.07 mL |
5 mM | 0.46 mL | 2.31 mL | 4.61 mL |
*The above data is based on the productmolecular weight 433.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.