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DPH
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
DPH图片
CAS NO:484049-04-9
规格:98%
分子量:336.32
包装与价格:
包装价格(元)
100mg电议
200mg电议
10mg电议
50mg电议

产品介绍
DPH 是一种有效的,细胞渗透的 c-Abl 激活剂,在酶和细胞活动中,能够有效刺激 c-Abl 的活化。
CAS:484049-04-9
分子式:C18H13FN4O2
分子量:336.32
纯度:98%
存储:Store at -20°C

Background:

DPH is a potent cell permeable c-Abl activator, which displays potent enzymatic and cellular activity in stimulating c-Abl activation.


DPH binds to the myristoyl binding site and prevents the formation of the bent conformation of the αI helix through steric hindrance, a mode of action distinct from the previously identified allosteric c-Abl inhibitor, GNF-2, that also binds to the myristoyl binding site. DPH represents the first cell-permeable, small-molecule tool compound for c-Abl activation[1].



[1]. Yang J, et al. Discovery and characterization of a cell-permeable, small-molecule c-Abl kinase activator that binds to the myristoyl binding site. Chem Biol. 2011 Feb 25;18(2):177-86 [2]. Shapiro LP, et al. Corticosteroid-induced dendrite loss and behavioral deficiencies can be blocked by activation of Abl2/Arg kinase. Mol Cell Neurosci. 2017 Oct 26;85:226-234.