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Benznidazol(Ro 07-1051)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Benznidazol(Ro 07-1051)图片
CAS NO:22994-85-0
包装:100mg
规格:98%
市场价:981元
分子量:260.25

产品介绍
Benznidazol(Ro07-1051)是一种抗寄生虫药物,对哥伦比亚T.cruzi菌株的IC50值为20.35μM,目前已被用于治疗美洲锥虫病。
CAS:22994-85-0
分子式:C12H12N4O3
分子量:260.25
纯度:98%
存储:Store at -20°C

Background:

Benznidazol (Ro 07-1051) is an antiparasitic medication, with an IC50 of 20.35 μM for Colombian T. cruzi strains, and has been used in the treatment of Chagas disease[1][2].



Benznidazole (100 mg/kg/day, p.o., 30 days) produces a decrease in electrocardiographic alterations, fewer modifications in the affinity and density of cardiac-receptors, and few isolated areas of fibrosis in the heart, in mice infected with Trypanosoma cruzi Tulahuen strain or SGO-Z12 isolate and treated at 180 days post infection (p.i.) (i.e. chronic phase) with Benznidazole[1].|| Animal Model:|Mice infected with Trypanosoma cruzi Tulahuen strain or SGO-Z12[1]|Dosage:|100 mg/kg/day |Administration:|Orally for 30 days|Result:|Produced a decrease in electrocardiographic alterations, fewer modifications in the affinity and density of cardiac-receptors, and few isolated areas of fibrosis in the heart.


[1]. Bustamante JM, et al. Treatment with benznidazole or thioridazine in the chronic phase of experimental Chagas disease improves cardiopathy. Int J Antimicrob Agents. 2007 Jun;29(6):733-7. [2]. Luna KP, et al. In vitro susceptibility of Trypanosoma cruzi strains from Santander, Colombia, to hexadecylphosphocholine (miltefosine), nifurtimox and benznidazole. Biomedica. 2009 Sep;29(3):448-55.