SaikogeninA可从中药柴胡中提取，是一种二肽基肽酶IV(DPP-IV)抑制剂。
CAS：5092-09-1
分子式：C30H48O4
分子量：472.7
纯度：98%
存储：Store at -20°C

Background:

Saikogenin A, extracted from a Chinese herbal plant called Tsai-Fu, is a dipeptidyl peptidase-IV (DPP-IV) inhibitor.

Saikogenin A has certain inhibitory effect on the enzyme DPP-IV. At a concentration of 20 μg/mL DPP-IV inhibition is 47.6%. DPP-IV is a non-classical serine aminopeptidase from its amino terminus of polypeptides and proteins (N-terminus) removing Xaa-Pro dipeptide[1].

Saikogenin A, an anti-inflammatory drug, is present in the crude extract of a Chinese herbal plant called Tsai-Fu. Saikogenin A is less effective in adrenalectomized rats than in normal rats in reducing the carrageenin-induced edema. The anti-inflammatory action of Saikogenin A are due to an increase in corticosterone caused by the release of arenocorticotropic hormone (ACTH) and a direct effect on the process of inflammation[2].

[1]. Pharmaceutical application of saikogenin A. CN107375300A. [2]. Cheng JT, et al. Anti-inflammatory effect of Saikogenin A. Biochem Pharmacol. 1986 Aug 1;35(15):2483-7.