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Sennoside A
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Sennoside A图片
CAS NO:81-27-6
包装:20mg
规格:98%
市场价:1455元
分子量:862.74

产品介绍
Irritant laxative;mild MAO inhibitor
CAS:81-27-6
分子式:C42H38O20
分子量:862.74
纯度:98%
存储:Store at -20°C

Background:

IC50: N/A


Sennoside A is a dianthrone glycoside isolated from Rhei Rhizoma and senna leaf. Sennoside A and B have identical molecular weights and formulae. Sennosides were known as laxatives causing purgative actions through the biotransformation of rhein anthrone. Sennoside A was reported to have regionally differential effects on spontaneous contractions of colon.


In vitro: The gastroprotective activities of sennoside A was found to be due to the up-regulation of PGE2 and the inhibitions of H+/K+-ATPase activity. When measured the H+/K+-ATPase activities of sennoside A, the positive control exhibited inhibitions of 41.1% and 42.4% at 50 μM and 100 μM, whereas sennoside A showed dose-dependent inhibitions of 17.3% and 27.1% at 50 μM and 100 μM [1].


In vivo: In a rat model, sennoside A reduced gastric juice, total acidity and increased pH, indicating that proton pump inhibition reduces gastric acid secretion. Furthermore, sennoside A increased PGE2 in a concentration-dependent manner. Moreover, in the intestinal transporting and gastric emptying rate experiment, sennoside A was found to accelerate such GI motility. These results suggested sennoside A possessed significant gastroprotective activities and it might be useful for the gastric disease treatment [1].


Clinical trial: N/A


Reference:
[1] In Young HwangandChoon Sik Jeong.  Gastroprotective Activities of Sennoside A and Sennoside B via the Up-Regulation of Prostaglandin E2and the Inhibition of H+/K+-ATPase Biomol Ther (Seoul). 2015 Sep; 23(5): 458–464.