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2',3'-Dideoxyadenosine 5'-triphosphate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
2',3'-Dideoxyadenosine 5'-triphosphate图片
CAS NO:24027-80-3
包装:100uL
规格:98%
市场价:1255元
分子量:475.2

产品介绍
2',3'-Dideoxyadenosine 5'-triphosphate (ddATP) is an in vitro inhibitor of reverse transcriptases from retroviruses, including HIV-1 and visna (Kis = 20 and 37 nM, respectively).
CAS:24027-80-3
分子式:C10H16N5O11P3
分子量:475.2
纯度:98%
存储:Store at -20°C

Background:

2’,3’-Dideoxyadenosine 5’-triphosphate (ddATP) is an in vitro inhibitor of reverse transcriptases from retroviruses, including HIV-1 and visna (Kis = 20 and 37 nM, respectively). It also blocks, in vitro, mammalian and bacterial DNA polymerases. ddATP, produced intracellularly by the phosphorylation of exogenously supplied 2’,3’-dideoxyadenosine, competes with dATP, resulting in chain termination. Because of this activity, dideoxynucleoside 5’-triphosphates, including ddATP, are used to terminate chain extension produced by the Taq polymerase used in polymerase chain reactions. It is also an antagonist of the purinergic receptor P2X2/3 (pIC50 = 6.5).