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10'-Desmethoxystreptonigrin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
10'-Desmethoxystreptonigrin图片
CAS NO:136803-89-9
规格:98%
分子量:476.4
包装与价格:
包装价格(元)
500ug电议
2.5mg电议

产品介绍
10'-Desmethoxystreptonigrin is an antibiotic originally isolated from Streptomyces and a derivative of the antibiotic streptonigrin.
CAS:136803-89-9
分子式:C24H20N4O7
分子量:476.4
纯度:98%
存储:Store at -20°C

Background:

10’-Desmethoxystreptonigrin is an antibiotic originally isolated from Streptomyces and a derivative of the antibiotic streptonigrin. It is active against a variety of bacteria, including S. aureus, S. faecalis, E. coli, K. pneumoniae, and P. vulgaris (MICs = 0.4, 1.6, 3.1, 3.1 and 0.4 µg/ml, respectively). 10’-Desmethoxystreptonigrin is cytotoxic to HCT116 colon and A2780 ovarian cancer cells (IC50s = 0.004 and 0.001 µg/ml, respectively), as well as HCT116 cells resistant to etoposide and teniposide and cisplatin-resistant A2780 cells (IC50s = 0.003, 0.001, and 0.01 µg/ml, respectively). 10’-Desmethoxystreptonigrin is also an inhibitor of p21ras farnesylation (IC50 = 21 nM).