(6S)-Tetrahydrofolic acid is a diastereomer of tetrahydrofolic acid, a reduced form of folic acid that serves as a cofactor in methyltransferase reactions and is the major one-carbon carrier in one carbon metabolism.
CAS：71963-69-4
分子式：C19H23N7O6
分子量：445.4
纯度：98%
存储：Store at -20°C

Background:

(6S)-Tetrahydrofolic acid is a diastereomer of tetrahydrofolic acid , a reduced form of folic acid that serves as a cofactor in methyltransferase reactions and is the major one-carbon carrier in one carbon metabolism.¹(6S)-Tetrahydrofolic acid is 1,000-fold more active than the (6R) form at promoting the binding of fluorodeoxyuridylate to thymidylate synthase and 600-fold more active as a growth factor of P. cerevisiae.²(6S)-Tetrahydrofolic acid also has a low affinity and high dissociation rate for folate-binding protein.³

参考文献：

1. Ragsdale, S.W. Catalysis of methyl group transfers involving tetrahydrofolate and B12. Vitam. Horm. 79, 293-324 (2008).

2. Sato, J.K., Newman, E.M., and Moran, R.G. Preparation of (6R)-tetrahydrofolic acid and (6R)-5-formyltetrahydrofolic acid of high stereochemical purity. Anal. Biochem. 154(2), 516-524 (1986).

3. Nygren-Babol, L., Sternesjo, A., Jagerstad, M., et al. Affinity and rate constants for interactions of bovine folate-binding protein and folate derivatives determined by optical biosensor technology. Effect of stereoselectivity. J. Agric. Food. Chem. 53(13), 5473-5478 (2005).