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TCS ERK 11e(VX-11e)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
TCS ERK 11e(VX-11e)图片
CAS NO:896720-20-0
包装与价格:
包装价格(元)
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍

生物活性

TCS ERK 11e (VX-11e)是一种有效且选择性的细胞外信号相关激酶2(ERK2)抑制剂(ERK2,GSK-3,Aurora激酶A和Cdk2的Ki值分别<2、395、540和852 nM)。有效阻断HT29细胞的增殖(IC50 = 48 nM)。

Targets

TargetValue
ERK2ki:<2nM
GSK3ki: 400nM
AURAki: 540nM
CDK2ki: 850nM
FLT3ki: 1.4μM
ROCK1ki: 1.4μM
JNK3ki: 1.4μM
TAK1ki: 3μM
PKAki: >4μM
SRCki: >4μM
JAK2ki: >4μM
JAK3ki: >4μM
SYKki: >4μM
METki: >4μM
IRAK4ki: >4μM
AKT3ki: >4μM
KDRki: >4μM
MEK1ki: >4μM
P38αki: >4μM
COTki: >4μM
ITKki: >4μM
MEKK3ki: >4μM
PLK1ki: >4μM
ZAP70ki: >4μM
IKki: ki: >5μM
NIKki: >5μM
CITki: >10μM
FAKki: >10μM

化学数据

目录号A12505
作用机制Inhibitor (抑制剂)
M. Wt500.35
FormulaC24H20Cl2FN5O2
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.896720-20-0
SMILESCC1=CN=C(N=C1C2=CNC(=C2)C(=O)N[C@H](CO)C3=CC(=CC=C3)Cl)NC4=C(C=C(C=C4)F)Cl

溶解度

In vitroDMSO94 mg/mL (187.87 mM)
WaterInsoluble
Ethanol15 mg/mL (29.97 mM)
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM19.99 mL99.93 mL199.86 mL
0.5 mM4 mL19.99 mL39.97 mL
1 mM2 mL9.99 mL19.99 mL
5 mM0.4 mL2 mL4 mL

*The above data is based on the productmolecular weight 500.35. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.