生物活性
Endoxifen是他莫昔芬的次生代谢产物。它是负责他莫昔芬在ER阳性乳腺癌中有效性的主要代谢物。Endoxifen Z-isomer抑制hERG, 这种作用具有浓度依赖性, IC50值为1.6μM。
化学数据
| 目录号 | A12639 |
| 作用机制 | Antagonist (拮抗剂) |
| M. Wt | 373.49 |
| Formula | C25H27NO2 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. | 112093-28-4 |
| SMILES | CCC(=C(C1=CC=C(C=C1)O)C2=CC=C(C=C2)OCCNC)C3=CC=CC=C3 |
储备液配制
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
| 0.1 mM | 26.77 mL | 133.87 mL | 267.74 mL |
| 0.5 mM | 5.35 mL | 26.77 mL | 53.55 mL |
| 1 mM | 2.68 mL | 13.39 mL | 26.77 mL |
| 5 mM | 0.54 mL | 2.68 mL | 5.35 mL |
*The above data is based on the productmolecular weight 373.49. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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