ML 10 is is a [18F] positron emission tomography (PET) radiotracer that accumulates in cells presenting apoptosis-specific membrane alterations. [18F]ML-10 allows for the detection of apoptotic cells located in atherosclerotic plaques. References: Bao X, Yang Z, Wang S, Zheng Y, Wang M, Gu B, Zhang J, Zhang Y, Zhang Y. The preclinical study of predicting radiosensitivity in human nasopharyngeal carcinoma xenografts by 18F-ML-10 animal- PET/CT imaging. Oncotarget. 2016 Mar 3. doi: 10.18632/oncotarget.7868. [Epub ahead of print] PubMed PMID: 26942701. 2: Médoc M, Dhilly M, Matesic L, Toutain J, Krause-Heuer AM, Delamare J, Fraser BH, Touzani O, Barré L, Greguric I, Sobrio F. In Vivo Evaluation of Radiofluorinated Caspase-3/7 Inhibitors as Radiotracers for Apoptosis Imaging and Comparison with [18F]ML-10 in a Stroke Model in the Rat. Mol Imaging Biol. 2016 Feb;18(1):117-26. doi: 10.1007/s11307-015-0865-1. PubMed PMID: 26013478. 3: Hyafil F, Tran-Dinh A, Burg S, Leygnac S, Louedec L, Milliner M, Ben Azzouna R, Reshef A, Ben Ami M, Meilhac O, Le Guludec D. Detection of Apoptotic Cells in a Rabbit Model with Atherosclerosis-Like Lesions Using the Positron Emission Tomography Radiotracer [18F]ML-10. Mol Imaging. 2015;14:433-42. PubMed PMID: 26431738. 4: Oborski MJ, Laymon CM, Lieberman FS, Drappatz J, Hamilton RL, Mountz JM. First use of (18)F-labeled ML-10 PET to assess apoptosis change in a newly diagnosed glioblastoma multiforme patient before and early after therapy. Brain Behav. 2014 Mar;4(2):312-5. doi: 10.1002/brb3.217. Epub 2014 Feb 12. PubMed PMID: 24683522; PubMed Central PMCID: PMC3967545. 5: Oborski MJ, Laymon CM, Qian Y, Lieberman FS, Nelson AD, Mountz JM. Challenges and Approaches to Quantitative Therapy Response Assessment in Glioblastoma Multiforme Using the Novel Apoptosis Positron Emission Tomography Tracer F-18 ML-10. Transl Oncol. 2014 Feb 1;7(1):111-9. eCollection 2014 Feb. PubMed PMID: 24772214; PubMed Central PMCID: PMC3998694. 6: Kadirvel M, Fairclough M, Cawthorne C, Rowling EJ, Babur M, McMahon A, Birkket P, Smigova A, Freeman S, Williams KJ, Brown G. Detection of apoptosis by PET/CT with the diethyl ester of [18F]ML-10 and fluorescence imaging with a dansyl analogue. Bioorg Med Chem. 2014 Jan 1;22(1):341-9. doi: 10.1016/j.bmc.2013.11.019. Epub 2013 Nov 20. PubMed PMID: 24290974. 7: Sobrio F, Médoc M, Martial L, Delamare J, Barré L. Automated radiosynthesis of [(18)F]ML-10, a PET radiotracer dedicated to apoptosis imaging, on a TRACERLab FX-FN module. Mol Imaging Biol. 2013 Feb;15(1):12-8. doi: 10.1007/s11307-012-0574-y. PubMed PMID: 22752653. 8: Allen AM, Ben-Ami M, Reshef A, Steinmetz A, Kundel Y, Inbar E, Djaldetti R, Davidson T, Fenig E, Ziv I. Assessment of response of brain metastases to radiotherapy by PET imaging of apoptosis with 18F-ML-10. Eur J Nucl Med Mol Imaging. 2012 Sep;39(9):1400-8. doi: 10.1007/s00259-012-2150-8. Epub 2012 Jun 15. PubMed PMID: 22699524. 9: Hoglund J, Shirvan A, Antoni G, Gustavsson SA, Langstrom B, Ringheim A, Sorensen J, Ben-Ami M, Ziv I. 18F-ML-10, a PET tracer for apoptosis: first human study. J Nucl Med. 2011 May;52(5):720-5. doi: 10.2967/jnumed.110.081786. Epub 2011 Apr 15. Erratum in: J Nucl Med. 2011 Nov;52(11):1818. PubMed PMID: 21498526. 10: Kohler H, Zschiedrich H, Clasen R, Linfante A, Gamm H. [The effects of 500 ml 10% hydroxyethyl starch 200/0.5 and 10% dextran 40 on blood volume, colloid osmotic pressure and renal function in human volunteers (author's transl)]. Anaesthesist. 1982 Feb;31(2):61-7. German. PubMed PMID: 6177264. 1 Chopra A. 2-(5-[(18)F]Fluoro-pentyl)-2-methyl-malonic acid (ML-10). 2012 Aug 15 [updated 2012 Sep 27]. Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004-2013. Available from .gov/books/NBK100897/ PubMed PMID: 23035304.

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