生物活性
SCH900776 (S-isomer)是靶向细胞周期检查点激酶1（Chk1）抑制剂，无细胞试验中IC50为3 nM，比作用于Chk2选择性高500倍。具有潜在的放射增敏和化学增敏活性。
化学数据
| 目录号 | A12703 |
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 376.25 |
| Formula | C15H18BrN7 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. | 891494-64-7 |
| Synonyms | SCH-900776; SCH 900776 |
| SMILES | CN1C=C(C=N1)C2=C3N=C(C(=C(N3N=C2)N)Br)[C@H]4CCCNC4 |
储备液配制
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
| 0.1 mM | 26.58 mL | 132.89 mL | 265.78 mL |
| 0.5 mM | 5.32 mL | 26.58 mL | 53.16 mL |
| 1 mM | 2.66 mL | 13.29 mL | 26.58 mL |
| 5 mM | 0.53 mL | 2.66 mL | 5.32 mL |
*The above data is based on the productmolecular weight 376.25. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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