生物活性
NU7026是一种新型的在无细胞试验中IC50为0.23 μM，作用于DNA-PK比作用于PI3K选择性高60倍，对ATM和ATR没有抑制活性。可增强用于治疗白血病的拓扑异构酶II毒物的细胞毒性。
靶点信息
| DNA-PK (Cell-free assay) | PI3K (Cell-free assay) | ATM (Cell-free assay) | ATR (Cell-free assay) | |
| 0.23 μM | 13 μM | >100 μM | >100 μM | |
化学数据
| 目录号 | A12752 |
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 281.31 |
| Formula | C17H15NO3 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. | 154447-35-5 |
| Synonyms | NU 7026, NU-7026 |
| SMILES | C1COCCN1C2=CC(=O)C3=C(O2)C4=CC=CC=C4C=C3 |
溶解度
| In vitro (25°C) | DMSO | 1 mg/mL (3.55 mM) |
| Water | Insoluble |
| Ethanol | Insoluble |
| In vivo | 1% DMSO+30% polyethylene glycol+1% Tween 80 | 28 mg/mL |
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
| 0.1 mM | 35.55 mL | 177.74 mL | 355.48 mL |
| 0.5 mM | 7.11 mL | 35.55 mL | 71.1 mL |
| 1 mM | 3.55 mL | 17.77 mL | 35.55 mL |
| 5 mM | 0.71 mL | 3.55 mL | 7.11 mL |
*The above data is based on the productmolecular weight 281.31. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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