Netilimicin is an aminoglycoside antibiotic.
CAS：56391-57-2
分子式：C21H41N5O7.2.5H2SO4
分子量：720.8
纯度：98%
存储：Store at -20°C

Background:

Netilimicin is an aminoglycoside antibiotic. It is active against S. aureus, N. gonorrhoeae, E. coli, P. mirabilis, and P. aeruginosa (MICs = 0.4, 3.1, 0.8, 1.6, and 0.4 µg/ml, respectively) as well as Enterococci, Enterobacter, Citrobacter, and Klebsiella species (MICs = 3.1, 0.4, 0.8, and ≤0.2 µg/ml, respectively). Netilimicin induces nephrotoxicity in rats when administered at doses ranging from 50 to 150 mg/kg. It also induces neuromuscular block, decreasing twitch tension in isolated diaphragm and soleus muscles in rabbits (ED50s = 18.5 and 62.2 mg/kg, respectively). Formulations containing netilimicin were previously used in the intravenous treatment of severe bacterial infections.