您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > Humanin
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Humanin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Humanin图片
CAS NO:330936-69-1
规格:98%
分子量:2687.2
包装与价格:
包装价格(元)
500ug电议
1mg电议

产品介绍
Humanin is a neuroprotective peptide.
CAS:330936-69-1
分子式:C119H204N34O32S2
分子量:2687.2
纯度:98%
存储:Store at -20°C

Background:

Humanin is a neuroprotective peptide. It completely blocks amyloid-β (1-42) (Aβ42) and Aβ43-induced cell death of primary cortical neurons when used at a concentration of 10 μM. Humanin also prevents amyloid precursor protein (APP) antibody-induced cell death and reduces neurotoxicity in FH11 cells induced by the APP mutants A617G-APP, L648P-APP, V642I-APP, and NL-APP, which are associated with familial Alzheimer's disease (IC50s = 0.1-1 μM). In vivo, humanin (0.375 mg/kg per hour) increases systemic insulin sensitivity and enhances glucose uptake in skeletal muscle of rats.