MK761 is a new class of compound which has beta adrenoceptor antagonist and vasodilating properties in a single molecule. The compound has in vitro beta adrenoceptor blocking activity in the isolated cat heart papillary muscle and isolated rat atria. It is approximately as potent as timolol and pindolol in blocking cardiac and vascular beta adrenergic receptors. References: Sweet CS, Hall RA, Columbo JM, Wenger HC, Backlund E, Morgan G, Gaul SL, Scriabine A. Beta adrenoceptor blocking properties of MK-761. J Pharmacol Exp Ther. 1979 Oct;211(1):195-9. PubMed PMID: 40012. 2: Sweet CS, Scriabine A, Weitz D, Ludden CT, Minsker DH, Stone CA. Antihypertensive and hemodynamic properties of 2-(3-tert-butylamino-2-hydroxypropoxy)-3-cyanopyridine HCl (MK-761). J Pharmacol Exp Ther. 1979 Oct;211(1):200-6. PubMed PMID: 114619. 3: Mostaghim R, Maddox YT, Ramwell PW. Endothelial potentiation of relaxation response to beta adrenoceptor blocking agents. J Pharmacol Exp Ther. 1986 Dec;239(3):797-801. PubMed PMID: 2879033. 4: Scriabine A, Ludden CT, Morgan G, Baldwin JJ. Antihypertensive and cardiac effects of two novel beta-adrenoceptor blocking drugs. Experientia. 1979 Dec 15;35(12):1634-7. PubMed PMID: 42553. 5: Sybertz EJ, Baum T, Pula KK, Nelson S, Eynon E, Sabin C. Studies on the mechanism of the acute antihypertensive and vasodilator actions of several beta-adrenoceptor antagonists. J Cardiovasc Pharmacol. 1982 Sep-Oct;4(5):749-58. PubMed PMID: 6182405. 6: Lefer AM, Lefer DJ, Levin RJ. Actions of non-cardiodepressant beta-adrenergic blocking agents in hemorrhagic shock. Adv Shock Res. 1980;3:167-74. PubMed PMID: 6118024. 7: Baum T, Sybertz EJ. Antihypertensive actions of an isomer of labetalol and other vasodilator-beta-adrenoceptor blockers. Fed Proc. 1983 Feb;42(2):176-81. PubMed PMID: 6130003. 8: Vickers S, Duncan CA, Arison BH, Davies RO, Ferguson R, Zacchei AG. The metabolic disposition of (S)-2-(3-tert-butylamino-2-hydroxypropoxy)-3-cyanopyridine in rats, dogs, and humans. Drug Metab Dispos. 1980 May-Jun;8(3):163-7. PubMed PMID: 6104580. 9: McClure DE, Baldwin JJ, Randall WC, Lyon TF, Mensler K, Lundell GF, Raab AW, Gross D, Risley EA, Sweet CS, Williams M. Antihypertensive beta-adrenergic blocking agents: N-aralkyl analogues of 2-[3-(tert-butylamino)-2-hydroxypropoxy]-3-cyanopyridine. J Med Chem. 1983 May;26(5):649-57. PubMed PMID: 6132999.

纯度：≥98%

CAS：65321-41-7