MKC-8866 (ORIN-1001; IRE1-IN-8866) is a salicylaldehyde analog that acts ass a potent, selective IRE1 RNase inhibitor with an IC50
of 0.29 μM in human vitro. MKC8866 strongly inhibits
Dithiothreitol-induced X-box-binding protein 1-spliced (XBP1s)
expression with an EC50 of 0.52 μM and unstresses RPMI 8226 cells with an IC50
of 0.14 μM. MKC8866 inhibits IRE1 RNase in breast cancer cells leading
to the decreased production of pro-tumorigenic factors and it can
inhibits prostate cancer (PCa) tumor growth.
纯度:≥98%
CAS:1338934-59-0