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Acetyl Angiotensinogen(1-14),porcine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Acetyl Angiotensinogen(1-14),porcine图片
CAS NO:66641-26-7
规格:98%
分子量:1801.05
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议

产品介绍
Angiotensinogen precursor
CAS:66641-26-7
分子式:C87H125N21O21
分子量:1801.05
纯度:98%
存储:Store at -20°C

Background:

Acetyl Angiotensinogen (1-14),porcine, (C87H125N21O21) is a peptide with the sequence AC-ASP-ARG-VAL-TYR-ILE-HIS-PRO-PHE-HIS-LEU-LEU-VAL-TYR-SER-OH, MW= 1801.05. The protein encoded by the Angiotensinogen gene is known as pre-angiotensinogen or angiotensinogen precursor. Pre-angiotensinogen is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure1. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. Angiotensin II is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia2. Mutations in the gene are associated with susceptibility to essential hypertension and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in the gene have also been associated with non-familial structural atrial fibrillation and inflammatory bowel disease.


参考文献:
1. Basso N, Terragno NA (December 2001). "History about the discovery of the renin-angiotensin system". Hypertension 38 (6): 1246–9.
2. Skurk T, Lee YM, Hauner H (May 2001). "Angiotensin II and its metabolites stimulate PAI-1 protein release from human adipocytes in primary culture". Hypertension 37 (5): 1336–40.