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Ophiopogonin D
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Ophiopogonin D图片
CAS NO:41753-55-3
包装:20mg
规格:98%
市场价:2315元
分子量:854.47

产品介绍
Extracted from Radix Liriopes;Store the product in sealed,cool and dry condition
CAS:41753-55-3
分子式:C44H70O16
分子量:854.47
纯度:98%
存储:Store at -20°C

Background:

Ophiopogonin D, isolated from the tubers of Ophiopogon japonicus, is a rare naturally occurring C29 steroidal glycoside[1]. Ophiopogonin D is a CYP2J3 inducer that significantly inhibits Ang II induced NF-κB nuclear translocation, IκBα down-regulation, intracellular Ca2+ overload and activation of pro-inflammatory cytokines by increasing the expression of CYP2J2/EETs and PPARα in human umbilical vein endothelial cells (HUVECs). Ophiopogonin D has been used to treat inflammatory and cardiovascular diseases for thousands of years[2].


参考文献:
[1]. Wang L , et al. Homo-aro-cholestane, furostane and spirostane saponins from the tubers of Ophiopogonjaponicus. Phytochemistry. 2017 Apr;136:125-132.
[2]. Huang X, et al. Ophiopogonin D and EETs ameliorate Ang II-induced inflammatory responses via activating PPARα in HUVECs. Biochem Biophys Res Commun. 2017 Aug 19;490(2):123-133.