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Enniatin B1
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Enniatin B1图片
CAS NO:19914-20-6
规格:98%
分子量:653.9
包装与价格:
包装价格(元)
1mg电议
5mg电议

产品介绍
Enniatins are cyclohexadepsipeptides commonly isolated from fungi and are known to have antibiotic properties.
CAS:19914-20-6
分子式:C34H59N3O9
分子量:653.9
纯度:98%
存储:Store at -20°C

Background:

Enniatin B1 is a Fusarium mycotoxin. Enniatin B1 inhibits acyl-CoA: cholesterol acyltransferase (ACAT) activity with an IC50 of 73 μM in an enzyme assay using rat liver microsomes[1]. Enniatin B1 crosss the blood-brain barrier[2]. Enniatin B1 decreases the activation of ERK (p44/p42). Enniatin B1 inhibits moderately TNF-α-induced NF-κB activation[3].


CCF-STTG1 cells are sensitive to Enniatin B1 (IC50=4.4 μM)[2].


参考文献:
[1]. Tomoda H, et al. Inhibition of acyl-CoA: cholesterol acyltransferase activity by cyclodepsipeptide antibiotics. J Antibiot (Tokyo). 1992 Oct;45(10):1626-32.
[2]. Krug I, et al. Transport of enniatin B and enniatin B1 across the blood-brain barrier and hints for neurotoxic effects in cerebral cells. PLoS One. 2018 May 16;13(5):e0197406.
[3]. W?tjen W, et al. Enniatins A1, B and B1 from an endophytic strain of Fusarium tricinctum induce apoptotic cell death in H4IIE hepatoma cells accompanied by inhibition of ERK phosphorylation. Mol Nutr Food Res. 2009 Apr;53(4):431-40.