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3-Deazauridine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
3-Deazauridine图片
CAS NO:23205-42-7
规格:98%
分子量:243.2
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议

产品介绍
3-Deazauridine is a nucleoside analog.
CAS:23205-42-7
分子式:C10H13NO6
分子量:243.2
纯度:98%
存储:Store at -20°C

Background:

3-Deazauridine is a nucleoside analog. It is converted intracellularly to 3-deazauridine triphosphate, which competitively inhibits cytidine triphosphate synthetase thereby inhibiting biosynthesis of the nucleic acid cytidine 5’-triphosphate (CTP). 3-Deazauridine inhibits the growth of L1210 leukemia cells when used at a concentration of 6 µM and dose-dependently reduces mortality in a mouse model of leukemia. It also enhances the incorporation of decitabine into DNA in HL-60 myeloid and MOLT-3 lymphoid leukemia cells when used at a concentration of 20 µM. 3-Deazauridine (100 or 150 mg/kg), when combined with decitabine, reduces mortality in an L1210 leukemia mouse model.