CAS NO: | 130603-59-7 |
规格: | 98% |
分子量: | 304.3 |
包装 | 价格(元) |
1mg | 电议 |
5mg | 电议 |
Background:
Piperafizine A is a natural methylated diketopiperazine first isolated from an actinomycete, Streptoverticillium. It potentiates the cytotoxicity of vincristine , an anti-cancer alkaloid known to be exported from cells by P-glycoprotein. Piperafizine A directs the intracellular accumulation of vincristine in cancer cells to a similar degree as verapamil , a P-glycoprotein inhibitor. The effects of piperafizine A on vincristine accumulation in cancer cells is dose-dependent over a range of 1 to 20 µg/ml.