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Verbascoside
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Verbascoside图片
CAS NO:61276-17-3
规格:98%
分子量:624.59
包装与价格:
包装价格(元)
10mg电议
50mg电议
100mg电议

产品介绍
PKC/NF-κB inhibitor
CAS:61276-17-3
分子式:C29H36O15
分子量:624.59
纯度:98%
存储:Store at -20°C

Background:

Verbascoside (Acteoside) is a hydroxytyrosol and phenylpropanoid sugar ester and an inhibitor of PKC and NF-κB [1].


Verbascoside has been found to decrease tyrosinase activity and melanin biosynthesis by regulating ERK signaling, and inhibit mycotoxin-mediated cell damage. In addition, Verbascoside has been reported to decrease the RANKL-stimulated differentiation of RAW264.7 cells and osteoclast formation. Moreover, Verbascoside has shown the inhibition of osteoclast formation in bone marrow macrophages (BMMs)with IC50 value of 4.8μM. Apart from these, Verbascoside has also been revealed to prevent these RANKL-induced increases in p-p38, p-ERK, p-JNK and the levels of phosphorylated MAPKs by immunometric analysis in macrophages. Furthermore, Verbascoside has been reported to inhibit RANKL-induced activation of NF-κB-DNA binding [1].


参考文献:
[1] Lee SY1, Lee KS, Yi SH, Kook SH, Lee JC. Acteoside suppresses RANKL-mediated osteoclastogenesis by inhibiting c-Fos induction and NF-κB pathway and attenuating ROS production. PLoS One. 2013 Dec 4;8(12):e80873. doi: 10.1371/journal.pone.0080873. eCollection 2013.